Dirk Daelemans: search on Z-Library

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1

Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs

Wang, Zhao, Yu, Zhao, Kang, Dongwei, Zhang, Jian, Tian, Ye, Daelemans, Dirk, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong

Journal:

Bioorganic & Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.57 MB

english, 2018

2

Studies on anti-HIV quinolones: New insights on the C-6 position

Serena Massari, Dirk Daelemans, Giuseppe Manfroni, Stefano Sabatini, Oriana Tabarrini, Christophe Pannecouque, Violetta Cecchetti

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 276 KB

english, 2009

3

The discovery of novel diarylpyri(mi)dine derivatives with high level activity against a wide variety of HIV-1 strains as well as against HIV-2

Lu, Xueyi, Yang, Jiapei, Kang, Dongwei, Gao, Ping, Daelemans, Dirk, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong

Journal:

Bioorganic & Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.14 MB

english, 2018

4

5-Hydroxypyrido[2,3- b ]pyrazin-6(5 H )-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase

Sun, Lin, Gao, Ping, Dong, Guanyu, Zhang, Xujie, Cheng, Xiqiang, Ding, Xiao, Wang, Xueshun, Daelemans, Dirk, De Clercq, Erik, Pannecouque, Christophe, Menéndez-Arias, Luis, Zhan, Peng, Liu, Xinyong

Journal:

European Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 796 KB

english, 2018

5

Selective inhibition of Human Immunodeficiency Virus type 1 (HIV-1) by a novel family of tricyclic nucleosides

María-Cruz Bonache, Alessandra Cordeiro, Ernesto Quesada, Els Vanstreels, Dirk Daelemans, María-José Camarasa, Jan Balzarini, Ana San-Félix

Journal:

Antiviral Research

Year:

2011

Language:

english

File:

PDF, 710 KB

english, 2011

6

A stably expressed llama single-domain intrabody targeting Rev displays broad-spectrum anti-HIV activity

Boons, Eline, Li, Guangdi, Vanstreels, Els, Vercruysse, Thomas, Pannecouque, Christophe, Vandamme, Anne-Mieke, Daelemans, Dirk

Journal:

Antiviral Research

Year:

2014

Language:

english

File:

PDF, 3.07 MB

english, 2014

7

Iron/Copper Co-Catalyzed Cross-Coupling Reaction for the Synthesis of 6-Substituted 7-Deazapurines and the Corresponding Nucleosides

Li, Qingfeng, Persoons, Leentje, Daelemans, Dirk, Herdewijn, Piet

Journal:

Journal of Organic Chemistry

Year:

2019

Language:

english

File:

PDF, 1.43 MB

english, 2019

8

Some Hydrazones of 2-Aroylamino-3-methylbutanohydrazide: Synthesis, Molecular Modeling Studies, and Identification as Stereoselective Inhibitors of HIV-1

Tatar, Esra, Küçükgüzel, İlkay, Daelemans, Dirk, Talele, Tanaji T., Kaushik-Basu, Neerja, De Clercq, Erik, Pannecouque, Christophe

Journal:

Archiv der Pharmazie

Year:

2013

Language:

english

File:

PDF, 358 KB

english, 2013

9

Discovery of Novel Diarylpyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the “NNRTI Adjacent” Binding Site

Huo, Zhipeng, Zhang, Heng, Kang, Dongwei, Zhou, Zhongxia, Wu, Gaochan, Desta, Samuel, Zuo, Xiaofang, Wang, Zhao, Jing, Lanlan, Ding, Xiao, Daelemans, Dirk, De Clercq, Erik, Pannecouque, Christophe, Zh

Journal:

ACS Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 836 KB

english, 2018

10

An Intrabody based on a Llama Single-domain Antibody Targeting the N-terminal α-Helical Multimerization Domain of HIV-1 Rev Inhibits Viral Replication

Dirk Daelemans, Thomas Vercruysse, Els Pardon, Els Vanstreels, Jan Steyaert

Journal:

Antiviral Research

Year:

2010

Language:

english

File:

PDF, 68 KB

english, 2010

11

Synthesis and biological evaluation of pyrrolo[2,1-f][1,2,4]triazine C-nucleosides with a ribose, 2'-deoxyribose, and 2',3'-dideoxyribose sugar moiety

Li, Qingfeng, Lescrinier, Eveline, Groaz, Elisabetta, Persoons, Leentje, Daelemans, Dirk, Herdewijn, Piet, De Jonghe, Steven

Journal:

Year:

2017

Language:

english

File:

PDF, 1.57 MB

english, 2017

12

Design, synthesis, and biological evaluation of piperidinylâsubstituted [1,2,4]triazolo[1,5âa]pyrimidine derivatives as potential antiâHIVâ1 agents with reduced cytotoxicity

Huang, Boshi, Kang, Dongwei, Tian, Ye, Daelemans, Dirk, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong

Journal:

Chemical Biology & Drug Design

Year:

2020

File:

PDF, 1.09 MB

2020

13

A time-of–drug addition approach to target identification of antiviral compounds

Daelemans, Dirk, Pauwels, Rudi, De Clercq, Erik, Pannecouque, Christophe

Journal:

Nature Protocols

Year:

2011

Language:

english

File:

PDF, 900 KB

english, 2011

14

Computational investigation of the HIV-1 Rev multimerization using molecular dynamics simulations and binding free energy calculations

Tom Venken, Dirk Daelemans, Marc De Maeyer, Arnout Voet

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2012

Language:

english

File:

PDF, 2.04 MB

english, 2012

15

Debio-025 inhibits HIV-1 by interfering with an early event in the replication cycle

Dirk Daelemans, Jean-Maurice Dumont, Brigitte Rosenwirth, Erik De Clercq, Christophe Pannecouque

Journal:

Antiviral Research

Year:

2010

Language:

english

File:

PDF, 362 KB

english, 2010

16

CXCR4 Chemokine Receptor Antagonists from Ultra-rigid Metal Complexes Profoundly Inhibit HIV-1 Replication, and also AMD3100-resistant Strains

Stephen J. Archibald, Dirk Daelemans, Timothy J. Hubin, Dana Huskens, Dominique Schols, Kristel Van Laethem, Erik De Clercq, Christophe Pannecouque

Journal:

Antiviral Research

Year:

2009

Language:

english

File:

PDF, 139 KB

english, 2009

17

Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: Synthesis, biological investigation and molecular modeling studies

Wu, Hai-Qiu, Yan, Zi-Hong, Chen, Wen-Xue, He, Qiu-Qin, Chen, Fen-Er, De Clercq, Erik, Balzarini, Jan, Daelemans, Dirk, Pannecouque, Christophe

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.01 MB

english, 2013

18

Discovery of piperidin-4-yl-aminopyrimidine derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

Wan, Zheng-Yong, Yao, Jin, Tao, Yuan, Mao, Tian-Qi, Wang, Xin-Long, Lu, Yi-Pei, Wang, Hai-Feng, Yin, Hong, Wu, Yan, Chen, Fen-Er, De Clercq, Erik, Daelemans, Dirk, Pannecouque, Christophe

Journal:

European Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.11 MB

english, 2015

19

Discovery of Novel Diarylpyrimidines as Potent HIV-1 NNRTIs by Investigating the Chemical Space of Less Explored “Hydrophobic Channel”

Zhou, xia Zhong, Liu, Tao, Kang, Dongwei, Huo, zhipeng, Wu, Gaochan, Daelemans, Dirk, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong

Journal:

Organic & Biomolecular Chemistry

Year:

2017

Language:

english

File:

PDF, 1.24 MB

english, 2017

20

C9orf72-generated poly-GR and poly-PR do not directly interfere with nucleocytoplasmic transport

Vanneste, Joni, Vercruysse, Thomas, Boeynaems, Steven, Sicart, Adria, Van Damme, Philip, Daelemans, Dirk, Van Den Bosch, Ludo

Journal:

Scientific Reports

Year:

2019

Language:

english

File:

PDF, 6.20 MB

english, 2019

21

Drug repurposing: phosphate prodrugs of anticancer and antiviral FDA-approved nucleosides as novel antimicrobials

Pertusati, Fabrizio, Pileggi, Elisa, Richards, Jennifer, Wootton, Mandy, Van Leemputte, Thijs, Persoons, Leentje, De Coster, David, Villanueva, Xabier, Daelemans, Dirk, Steenackers, Hans, McGuigan, Ch

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2020

File:

PDF, 615 KB

2020

22

Studies of Anti-HIV Transcription Inhibitor Quinolones: Identification of Potent N1-Vinyl Derivatives

Prof. Oriana Tabarrini, Dr. Serena Massari, Dr. Dirk Daelemans, Dr. Francesco Meschini, Dr. Giuseppe Manfroni, Dr. Laura Bottega, Prof. Barbara Gatto, Prof. Manlio Palumbo, Prof. Christophe Pannecouqu

Journal:

Year:

2010

Language:

english

File:

PDF, 416 KB

english, 2010

23

Tetrazolium-based colorimetric assay for the detection of HIV replication inhibitors: revisited 20 years later

Daelemans, Dirk, De Clercq, Erik, Pannecouque, Christophe

Journal:

Nature Protocols

Year:

2008

Language:

english

File:

PDF, 289 KB

english, 2008

24

High-throughput In Vitro HIV Rev-multimerization Assay

Thomas Vercruysse, George Pavlakis, Dirk Daelemans

Journal:

Antiviral Research

Year:

2009

Language:

english

File:

PDF, 73 KB

english, 2009

25

Exploiting the anti-HIV 6-desfluoroquinolones to design multiple ligands

Sancineto, Luca, Iraci, Nunzio, Barreca, Maria Letizia, Massari, Serena, Manfroni, Giuseppe, Corazza, Gianmarco, Cecchetti, Violetta, Marcello, Alessandro, Daelemans, Dirk, Pannecouque, Christophe, Ta

Journal:

Bioorganic & Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.10 MB

english, 2014

26

Discovery of novel piperidine-substituted indolylarylsulfones as potent HIV NNRTIs via structure-guided scaffold morphing and fragment rearrangement

Li, Xiao, Gao, Ping, Huang, Boshi, Zhou, Zhongxia, Yu, Zhao, Yuan, Zheng, Liu, Huiqing, Pannecouque, Christophe, Daelemans, Dirk, De Clercq, Erik, Zhan, Peng, Liu, Xinyong

Journal:

European Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 898 KB

english, 2016

27

Discovery of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the Tolerant Region I of NNIBP

Kang, Dongwei, Ding, Xiao, Wu, Gaochan, Huo, Zhipeng, Zhou, Zhongxia, zhao, tong, Feng, Da, Wang, Zhao, Tian, Ye, Daelemans, Dirk, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong

Journal:

ACS Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 562 KB

english, 2017

28

Identification of Different Phenotypes of Interstitial Cells in the Upper and Deep Lamina Propria of the Human Bladder Dome

Gevaert, Thomas, Vanstreels, Els, Daelemans, Dirk, Franken, Jan, Van Der Aa, Frank, Roskams, Tania, De Ridder, Dirk

Journal:

The Journal of Urology

Year:

2014

Language:

english

File:

PDF, 815 KB

english, 2014

29

Understanding the molecular mechanism of host-based statin resistance in hepatitis C virus replicon containing cells

Delang, Leen, Scheers, Els, Grabner, Mareike, Verpaalen, Ben, Helsen, Nicky, Vanstreels, Els, Daelemans, Dirk, Verfaillie, Catherine, Neyts, Johan

Journal:

Biochemical Pharmacology

Year:

2015

Language:

english

File:

PDF, 1.66 MB

english, 2015

30

Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives targeting the entrance channel of NNRTI binding pocket

Yang, Jiapei, Chen, Wenmin, Kang, Dongwei, Lu, Xueyi, Li, Xiao, Liu, Zhaoqiang, Huang, Boshi, Daelemans, Dirk, Pannecouque, Christophe, De Clercq, Erik, Zhan, Peng, Liu, Xinyong

Journal:

European Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.06 MB

english, 2016

31

The stem cell growth factor receptor KIT is not expressed on interstitial cells in bladder

Gevaert, Thomas, Ridder, Dirk De, Vanstreels, Els, Daelemans, Dirk, Everaerts, Wouter, Aa, Frank Van Der, Pintelon, Isabel, Timmermans, Jean-Pierre, Roskams, Tania, Steiner, Clara, Neuhaus, Jochen

Journal:

Journal of Cellular and Molecular Medicine

Year:

2016

Language:

english

File:

PDF, 1.72 MB

english, 2016

32

Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus

Tian, Ye, Liu, Zhaoqiang, Liu, Jinghan, Huang, Boshi, Kang, Dongwei, Zhang, Heng, De Clercq, Erik, Daelemans, Dirk, Pannecouque, Christophe, Lee, Kuo-Hsiung, Chen, Chin-Ho, Zhan, Peng, Liu, Xinyong

Journal:

European Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 3.89 MB

english, 2018

33

Exploiting the Tolerant Region I of Non-nucleoside Reverse Transcriptase Inhibitor Binding Pocket (NNIBP): Discovery of Potent Diarylpyrimidine (DAPY)-typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles

Huang, Boshi, Chen, Wenmin, Zhao, Tong, Li, Zhenyu, Jiang, Xiangyi, Ginex, Tiziana, Vílchez, David, Luque, F. Javier, Kang, Dongwei, Gao, Ping, Zhang, Jian, Tian, Ye, Daelemans, Dirk, De Clercq, Erik,

Journal:

Journal of Medicinal Chemistry

Year:

2019

File:

PDF, 1.04 MB

2019

34

Structural Investigation of the Naphthyridone Scaffold: Identification of a 1,6-Naphthyridone Derivative with Potent and Selective Anti-HIV Activity

Prof. Oriana Tabarrini, Dr. Serena Massari, Dr. Luca Sancineto, Dr. Dirk Daelemans, Dr. Stefano Sabatini, Dr. Giuseppe Manfroni, Prof. Violetta Cecchetti, Prof. Christophe Pannecouque

Journal:

Year:

2011

Language:

english

File:

PDF, 303 KB

english, 2011

35

N,N′-Bis(1,2,3-thiadiazol-5-yl)benzene-1,2-diamine Targets the HIV-1 Retroviral Nucleocapsid Zinc Fingers

Christophe Pannecouque, Beata Szafarowicz, Natalia Volkova, Vasiliy Bakulev, Wim Dehaen, Yves Mély, Dirk Daelemans

Journal:

Antiviral Research

Year:

2010

Language:

english

File:

PDF, 72 KB

english, 2010

36

Acceptability of rilmenidine and long-term surveillance of plasma concentrations in hypertensive patients with renal insufficiency

Robert L. Lins, Ronald Daelemans, Max Dratwa, Dirk Verbeelen, Jacques Sennesael, Brigitte Brisgand, Norbert Lameire

Journal:

The American Journal of Medicine

Year:

1989

Language:

english

File:

PDF, 584 KB

english, 1989

37

Synthesis, biological evaluation and molecular modeling of 4,6-diarylpyrimidines and diarylbenzenes as novel non-nucleosides HIV-1 reverse transcriptase inhibitors

Ribone, Sergio R., Leen, Volker, Madrid, Marcela, Dehaen, Wim, Daelemans, Dirk, Pannecouque, Christophe, Briñón, Margarita C.

Journal:

European Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.00 MB

english, 2012

38

Comparative study of the organisation and phenotypes of bladder interstitial cells in human, mouse and rat

Gevaert, Thomas, Neuhaus, Jochen, Vanstreels, Els, Daelemans, Dirk, Everaerts, Wouter, Der Aa, Frank Van, Timmermans, Jean-Pierre, Roskams, Tania, Steiner, Clara, Pintelon, Isabel, De Ridder, Dirk

Journal:

Cell and Tissue Research

Year:

2017

Language:

english

File:

PDF, 28.15 MB

english, 2017

39

First discovery of a potential carbonate prodrug of NNRTI drug candidate RDEA427 with submicromolar inhibitory activity against HIV-1 K103N/Y181C double mutant strain

Huang, Boshi, Liu, Xinhao, Tian, Ye, Kang, Dongwei, Zhou, Zhongxia, Daelemans, Dirk, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 660 KB

english, 2018

40

S - Adenosylhomocysteine Hydrolase Inhibitors Interfere with the Replication of Human Immunodeficiency Virus Type 1 through Inhibition of the LTR Transactivation

Daelemans, Dirk, Esté, Jose A., Witvrouw, Myriam, Pannecouque, Christophe, Jonckheere, Heidi, Aquaro, Stefano, Perno, Carlo-Federico, Clercq, Erik De, Vandamme, Anne-Mieke

Journal:

Molecular Pharmacology

Year:

1997

Language:

english

File:

PDF, 151 KB

english, 1997

41

Synthesis and Antitumor Activity of C-7-Alkynylated and Arylated Pyrrolotriazine C-Ribonucleosides

Li, Qingfeng, Groaz, Elisabetta, Persoons, Leentje, Daelemans, Dirk, Herdewijn, Piet

Journal:

ACS Medicinal Chemistry Letters

Year:

2020

File:

PDF, 1.07 MB

2020

42

Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: Structure–activity relationship and mechanism of action

Tine Van Neck, Christophe Pannecouque, Els Vanstreels, Miguel Stevens, Wim Dehaen, Dirk Daelemans

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 433 KB

english, 2008

43

Molecular design, synthesis and biological evaluation of BP-O-DAPY and O-DAPY derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors

Yang, Shiqiong, Pannecouque, Christophe, Daelemans, Dirk, Ma, Xiao-Dong, Liu, Yang, Chen, Fen-Er, De Clercq, Erik

Journal:

European Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 2.73 MB

english, 2013

44

Structure−Activity Relationship Study on Anti-HIV 6-Desfluoroquinolones

Tabarrini, Oriana, Massari, Serena, Daelemans, Dirk, Stevens, Miguel, Manfroni, Giuseppe, Sabatini, Stefano, Balzarini, Jan, Cecchetti, Violetta, Pannecouque, Christophe, Fravolini, Arnaldo

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 129 KB

english, 2008

45

In Vivo HIV-1 Rev Multimerization in the Nucleolus and Cytoplasm Identified by Fluorescence Resonance Energy Transfer

Daelemans, Dirk, Costes, Sylvain V., Cho, Edward H., Erwin-Cohen, Rebecca A., Lockett, Stephen, Pavlakis, George N.

Journal:

Journal of Biological Chemistry

Year:

2004

Language:

english

File:

PDF, 1.09 MB

english, 2004

46

CXCR4 chemokine receptor antagonists: nickel(ii) complexes of configurationally restricted macrocycles

Smith, Rachel, Huskens, Dana, Daelemans, Dirk, Mewis, Ryan E., Garcia, Courtney D., Cain, Amy N., Freeman, TaRynn N. Carder, Pannecouque, Christophe, Clercq, Erik De, Schols, Dominique, Hubin, Timothy

Journal:

Dalton Transactions

Year:

2012

Language:

english

File:

PDF, 758 KB

english, 2012

47

Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-associated Variants

Kang, Dongwei, Fang, Zengjun, Huang, Boshi, Lu, Xueyi, Zhang, Heng, Xu, Haoran, Huo, Zhipeng, Zhou, Zhongxia, Yu, Zhao, Meng, Qing, Wu, Gaochan, Ding, Xiao, Tian, Ye, Daelemans, Dirk, De Clercq, Erik,

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.14 MB

english, 2017

48

Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors by exploring the structure-activity relationship of solvent-exposed regions I

Kang, Dongwei, Wang, Zhao, Chen, Meng, Feng, Da, Wu, Gaochan, Zhou, Zhongxia, Jing, Lanlan, Zuo, Xiaofang, Jiang, Xiangyi, Daelemans, Dirk, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, X

Journal:

Chemical Biology & Drug Design

Year:

2018

Language:

english

File:

PDF, 590 KB

english, 2018

49

Iron/Copper Co-Catalyzed Cross-Coupling Reaction for the Synthesis of 6-Substituted 7-Deazapurines and the Corresponding Nucleosides

Li, Qingfeng, Persoons, Leentje, Daelemans, Dirk, Herdewijn, Piet

Journal:

Journal of Organic Chemistry

Year:

2019

File:

PDF, 1.43 MB

2019

50

2-chloro-3-pyridin-3-yl-5,6,7,8-tetrahydroindolizine-1-carboxamide (CMV423), a new lead compound for the treatment of human cytomegalovirus infections

Robert Snoeck, Graciela Andrei, Bahram Bodaghi, Laurence Lagneaux, Dirk Daelemans, Erik de Clercq, Johan Neyts, Dominique Schols, Lieve Naesens, Susan Michelson, Dominique Bron, Michael J Otto, Anne B

Journal:

Antiviral Research

Year:

2002

Language:

english

File:

PDF, 236 KB

english, 2002

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